Sleep Medicine
Volume 1, Issue 2 , Pages 101-108, 1 April 2000

Narcolepsy and the ability to resist sleep

  • Dalia Shechter-Amir

      Affiliations

    • Sleep Disorders Clinic, University of Toronto Centre for Sleep and Chronobiology, Western Division of the Toronto Hospital, 399 Bathurst St, Toronto, ON M5T 2S8, Canada
    • ,
  • Judy A Wade

      Affiliations

    • Regional Histocompatability Laboratory of the Toronto Hospital, 399 Bathurst St, Toronto, ON M5T 2S8, Canada
    • ,
  • Harvey Moldofsky

      Affiliations

    • Sleep Disorders Clinic, University of Toronto Centre for Sleep and Chronobiology, Western Division of the Toronto Hospital, 399 Bathurst St, Toronto, ON M5T 2S8, Canada
    • Corresponding Author InformationCorresponding author. Tel.: +1-416-603-5109; fax:+1-416-603-2388

Received 25 August 1999; received in revised form 26 September 1999; accepted 2 December 1999.

Abstract 

We describe five patients who presented with irresistible daytime sleepiness and who have the clinical and laboratory features of narcolepsy but differ from most patients with narcolepsy in their ability to resist falling asleep during the daytime. All of the patients described partial or complete remission of their symptoms. Using an HLA marker, the expected haplotypes for narcolepsy were found, but no specific genetic features were found associated with chromosome 6p that differentiated this group from patients with typical narcolepsy. Problems are discussed in the laboratory assessment of such patients using both the multiple sleep latency test and the maintenance of wakefulness test.

Keywords:  Narcolepsy, Maintenance of wakefulness test, Remission, HLA

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PII: S1389-9457(99)00016-7

Sleep Medicine
Volume 1, Issue 2 , Pages 101-108, 1 April 2000

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