Sleep Medicine
Volume 1, Issue 2 , Pages 109-116 , 1 April 2000

A randomized trial of the long-term, continued efficacy and safety of modafinil in narcolepsy

  • H Moldofsky

      Affiliations

    • University of Toronto Centre for Sleep and Chronobiology, Toronto Western Hospital, Toronto, ON, Canada
    • Corresponding Author InformationCorresponding author. University of Toronto Centre for Sleep and Chronobiology, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada. Tel.: +1-416-603-5109; fax: +1-416-603-2388
    • ,
  • R.J Broughton

      Affiliations

    • Division of Neurology, the Ottawa Hospital (General Campus), Ottawa, ON, Canada
    • ,
  • J.D Hill

      Affiliations

    • Draxis Health Inc., Mississauga, ON, Canada

Received 1 October 1999 ,Revised 7 December 1999 ,Accepted 8 December 1999.

References 

  1. Besset A, Tafti M, Villemin E, Billiard M. Effet du modafinil (300 mg) sur le sommeil, la somnolence et la vigilance du narcoleptique. Neurophysiol Clin. 1993;23(47):60
  2. Billiard M, Besset A, Montplaisir J. Modafinil: a double-blind multicenter study. Sleep. 1994;17(Suppl):107–112
  3. Boivin DB, Montplaisir J, Petit D, Lambert C, et al.  The effects of modafinil on symptomatology of human narcolepsy. Clin Neuropharmacol. 1993;16(46):53
  4. Broughton R, Fleming J, George C, Hill J, et al.  Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy. Neurology. 1997;49(444):451
  5. US Modafinil in Narcolepsy Multicenter Study Group. Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy. Ann Neurol 1998;43:88–97.
  6. Bastugi H, Jouvet M. Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil. Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(695):700
  7. Laffont R, Mayer G, Minz M. Modafinil in diurnal sleepiness: a study of 123 patients. Sleep. 1994;17(Suppl):113–115
  8. Diagnostic Classification Steering Committee, Thorpy MJ Chairman. International classification of sleep disorders: diagnostic and scoring manual. Rochester, MN: American Sleep Disorders Association, 1990.
  9. Mitler MM, Gujavarty KS, Browman CP. Maintenance of wakefulness test: a polysomnographic technique for evaluating treatment efficacy in patients with excessive somnolence. Electroenceph Clin Neurophysiol. 1982;53(658):661
  10. Johns M. New method for measuring daytime sleepiness: the Epworth Sleepiness Scale. Sleep. 1991;14(540):555
  11. Wilkinson RT, Houghton D. Portable four-choice reaction time test with magnetic tape memory. Behav Res Meth Instrum. 1975;7(441):446
  12. McNair DM, Lorr M, Droppleman LF. Profile of mood states manual. San Diego CA: Educational and Industrial Testing Service, 1992.

PII: S1389-9457(99)00014-3

Sleep Medicine
Volume 1, Issue 2 , Pages 109-116 , 1 April 2000

Article Tools

* Image Usage & Resolution