Sleep Medicine
Volume 12, Supplement 2 , Pages S3-S10, December 2011

Agrypnia Excitata

  • Elio Lugaresi
    • ,
  • Federica Provini

      Affiliations

    • Corresponding Author InformationCorresponding author. Address: Dipartimento di Scienze Neurologiche, Università di Bologna, Via Ugo Foscolo 7, 40123 Bologna, Italy. Tel.: +39 051 2092950; fax: +39 051 2092963.
    • ,
  • Pietro Cortelli

IRCCS, Istituto delle Scienze Neurologiche, University of Bologna, Bologna, Italy

Received 21 September 2011; received in revised form 11 October 2011; accepted 11 October 2011.

Abstract 

The concept of Agrypnia excitata (AE) was originally proposed as a concept deriving from the clinical and anatomo-pathological observations obtained in three different diseases, Fatal familial insomnia (FFI), Delirium tremens (DT), and Morvan syndrome (MS). Agrypnia refers to a condition of severely reduced or absent sleep due to organic disorders. Excitata refers to the association of agrypnia with generalized motor and autonomic hyperactivation. AE is a syndrome that has been claimed to relate to a dysfunction in the thalamo-limbic circuits that govern sleep–wake cycles and autonomic activities.

Keywords: Fatal familial insomnia, Delirium tremens, Morvan syndrome, Agrypnia excitata, Sleep loss, Thalamus

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PII: S1389-9457(11)00315-7

doi:10.1016/j.sleep.2011.10.004

Sleep Medicine
Volume 12, Supplement 2 , Pages S3-S10, December 2011

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