Sleep Medicine
Volume 11, Issue 3 , Pages 325-328 , March 2010

A double-blind, crossover study of Doxazosin and Enalapril on peripheral vascular tone and nocturnal blood pressure in sleep apnea patients

  • Ding Zou

      Affiliations

    • Sleep Laboratory, Department of Pulmonary Medicine, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
    • Corresponding Author InformationCorresponding author. Tel.: +46 31 342 3599; fax: +46 31 825207.
  • ,
  • Ludger Grote

      Affiliations

    • Sleep Laboratory, Department of Pulmonary Medicine, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
  • ,
  • Derek N. Eder

      Affiliations

    • Sleep Laboratory, Department of Pulmonary Medicine, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
  • ,
  • Jakub Radlinski

      Affiliations

    • Department of Pathophysiology of Respiratory System, Institute for Tuberculosis and Lung Diseases Rabka-Zdrój Branch, Rabka-Zdrój, Poland
  • ,
  • Jan Hedner

      Affiliations

    • Sleep Laboratory, Department of Pulmonary Medicine, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden

Received 3 September 2009 ,Revised 13 October 2009 ,Accepted 26 October 2009.

References 

  1. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA. 2003;289(19):2560–2572
  2. Worsnop CJ, Naughton MT, Barter CE, Morgan TO, Anderson AI, Pierce RJ. The prevalence of obstructive sleep apnea in hypertensives. Am J Respir Crit Care Med. 1998;157(1):111–115
  3. Hedner J, Ejnell H, Sellgren J, Hedner T, Wallin G. Is high and fluctuating muscle nerve sympathetic activity in the sleep apnoea syndrome of pathogenetic importance for the development of hypertension?. J Hypertens Suppl. 1988;6(4):S529–S531
  4. Pepperell JC, Ramdassingh-Dow S, Crosthwaite N, Mullins R, Jenkinson C, Stradling JR, et al. Ambulatory blood pressure after therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised parallel trial. Lancet. 2002;359(9302):204–210
  5. Logan AG, Tkacova R, Perlikowski SM, Leung RS, Tisler A, Floras JS, et al. Refractory hypertension and sleep apnoea: effect of CPAP on blood pressure and baroreflex. Eur Respir J. 2003;21(2):241–247
  6. Kraiczi H, Hedner J, Peker Y, Grote L. Comparison of atenolol, amlodipine, enalapril, hydrochlorothiazide, and losartan for antihypertensive treatment in patients with obstructive sleep apnea. Am J Respir Crit Care Med. 2000;161(5):1423–1428
  7. Salo TM, Kantola I, Voipio-Pulkki LM, Pelttari L, Viikari JS. The effect of four different antihypertensive medications on cardiovascular regulation in hypertensive sleep apneic patients – assessment by spectral analysis of heart rate and blood pressure variability. Eur J Clin Pharmacol. 1999;55(3):191–198
  8. Schnall RP, Shlitner A, Sheffy J, Kedar R, Lavie P. Periodic, profound peripheral vasoconstriction – a new marker of obstructive sleep apnea. Sleep. 1999;22(7):939–946
  9. Bar A, Pillar G, Dvir I, Sheffy J, Schnall RP, Lavie P. Evaluation of a portable device based on peripheral arterial tone for unattended home sleep studies. Chest. 2003;123(3):695–703
  10. Zou D, Grote L, Peker Y, Lindblad U, Hedner J. Validation a portable monitoring device for sleep apnea diagnosis in a population based cohort using synchronized home polysomnography. Sleep. 2006;29(3):367–374
  11. Zou D, Grote L, Eder DN, Peker Y, Hedner J. Obstructive apneic events induce alpha-receptor mediated digital vasoconstriction. Sleep. 2004;27(3):485–489
  12. Taylor SH, Lee PS, Sharma SK. A comparison of doxazosin and enalapril in the treatment of mild and moderate essential hypertension. Am Heart J. 1988;116(6 Pt 2):1820–1825
  13. Ebbs D. A comparison of selected antihypertensives and the use of conventional vs. ambulatory blood pressure in the detection and treatment of hypertension. Cardiology. 2001;96(1):3–9
  14. Ben-Dov IZ, Ben-Arie L, Mekler J, Bursztyn M. How should patients treated with alpha-blockers be followed? Insights from an ambulatory blood pressure monitoring database. J Hypertens. 2006;24(5):861–865
  15. Kario K, Schwartz JE, Pickering TG. Changes of nocturnal blood pressure dipping status in hypertensives by nighttime dosing of alpha-adrenergic blocker, doxazosin: results from the HALT study. Hypertension. 2000;35(3):787–794
  16. Grassi G, Seravalle G, Stella ML, Turri C, Zanchetti A, Mancia G. Sympathoexcitatory responses to the acute blood pressure fall induced by central or peripheral antihypertensive drugs. Am J Hypertens. 2000;13(1):29–34
  17. Nitzan M, Glikberg F, Fidel J, Gross C, Bar-On H, Mahler Y. The relationship between systolic blood pressure and microvascular resistance in non-diabetic and diabetic subjects. J Basic Clin Physiol Pharmacol. 1992;3(3):193–205
  18. Zou D, Grote L, Radlinski J, Eder DN, Lindblad U, Hedner J. Nocturnal pulse wave attenuation is associated with office blood pressure in a population based cohort. Sleep Med. 2009;10(8):836–843

PII: S1389-9457(10)00067-5

doi: 10.1016/j.sleep.2009.10.004

Sleep Medicine
Volume 11, Issue 3 , Pages 325-328 , March 2010