Changes of cortical excitability after dopaminergic treatment in restless legs syndrome

Single-pulse transcranial magnetic stimulation (TMS). Motor evoked potential (MEP) amplitude elicited from the first dorsal interosseous muscle in the pre-treatment condition and in the post-treatment condition, tested at different times following a bimanual motor task. Note that only in the post-treatment condition is present a significant increment of MEP amplitude after the rest period (delayed facilitation). Standard error bars are shown.

Paired-pulse transcranial magnetic stimulation (TMS). The average time course at different inter-stimulus intervals (ISI) in the pre-treatment and post-treatment conditions. At each ISI, the size of the conditioned motor evoked potential (MEP) is expressed as a percentage of the size of the unconditioned MEP alone. Significant inhibition of the conditioned MEP is present only in the post-treatment condition. Standard error bars are shown.