Sleep Medicine
Volume 11, Issue 3 , Pages 310-313 , March 2010

Pregnancy accounts for most of the gender difference in prevalence of familial RLS

  • Nicholas P. Pantaleo

      Affiliations

    • Dept. of Psychology and Brain Science, Johns Hopkins Univ., Baltimore, MD, USA
    • ,
  • Wayne A. Hening

      Affiliations

    • UMDNJ-RW Johnson Medical Center, New Brunswick, NJ, USA
    • Deceased.
    • ,
  • Richard P. Allen

      Affiliations

    • Dept. of Neurology, Johns Hopkins Univ., Baltimore, MD, USA
    • Corresponding Author InformationCorresponding author. Address: Dept. of Neurology, Johns Hopkins Univ., Asthma and Allergy, Rm. 1B75B, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA. Tel.: +1 410 550 2609; fax: +1 410 550 3364.
    • ,
  • Christopher J. Earley

      Affiliations

    • Dept. of Neurology, Johns Hopkins Univ., Baltimore, MD, USA

Received 27 February 2009 ,Revised 8 April 2009 ,Accepted 16 April 2009.

References 

  1. Allen RP, Walters AS, Montplaisir J, Hening W, Myers A, Bell TJ, et al. Restless legs syndrome prevalence and impact: REST general population study. Arch Intern Med. 2005;165(11):1286–1292
  2. Bjorvatn B, Leissner L, Ulfberg J, Gyring J, Karlsborg M, Regeur L, et al. Prevalence, severity and risk factors of restless legs syndrome in the general adult population in two Scandinavian countries. Sleep Med. 2005;6(4):307–312
  3. Tison F, Crochard A, Leger D, Bouee S, Lainey E, El Hasnaoui A. Epidemiology of restless legs syndrome in French adults: a nationwide survey: the INSTANT study. Neurology. 2005;65(2):239–246
  4. Picchietti D, Allen RP, Walters AS, Davidson JE, Myers A, Ferini-Strambi L. Restless legs syndrome: prevalence and impact in children and adolescents – the Peds REST study. Pediatrics. 2007;120(2):253–266
  5. Manconi M, Govoni V, De Vito A, Tiberio Economou N, Cesnik E, Mollica G, et al. Pregnancy as a risk factor for restless legs syndrome. Sleep Med. 2004;5(3):305–308
  6. Berger K, Luedemann J, Trenkwalder C, John U, Kessler C. Sex and the risk of restless legs syndrome in the general population. Arch Intern Med. 2004;164(2):196–202
  7. Mathias RA, Hening W, Washburn M, Allen RP, Lesage S, Wilson AF, et al. Segregation analysis of restless legs syndrome: possible evidence for a major gene in a family study using blinded diagnoses. Hum Hered. 2006;62(3):157–164
  8. Hening WA, Allen RP, Washburn M, Lesage S, Earley CJ. Validation of the Hopkins telephone diagnostic interview for restless legs syndrome. Sleep Med. 2008;9(3):283–289
  9. Sforza E, Johannes M, Claudio B. The PAM-RL ambulatory device for detection of periodic leg movements: a validation study. Sleep Med. 2005;6(5):407–413
  10. Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisir J. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003;4(2):101–119
  11. Stefansson H, Rye DB, Hicks A, Petursson H, Ingason A, Thorgeirsson TE, et al. A Genetic risk factor for periodic limb movements in sleep. N Engl J Med. 2007;357(7):639–647
  12. Martin J, Hamilton B, Sutton P, Ventura S, Menacker G, Kimeyer S, et al. Births: final data for 2005. Natl Vital Stat Rep. 2007;56(6):1–104
  13. Gamaldo CE, Benbrook AR, Allen RP, Scott JA, Henning WA, Earley CJ. Childhood and adult factors associated with restless legs syndrome (RLS) diagnosis. Sleep Med. 2007;8(7–8):716–722
  14. Simakajornboon N, Gozal D, Vlasic V, Mack C, Sharon D, McGinley BM. Periodic limb movements in sleep and iron status in children. Sleep. 2003;26(6):735–738

PII: S1389-9457(09)00189-0

doi: 10.1016/j.sleep.2009.04.005

Sleep Medicine
Volume 11, Issue 3 , Pages 310-313 , March 2010

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