Sleep Medicine
Volume 10, Issue 10 , Pages 1090-1096 , December 2009

Cortical involvement in the sensory and motor symptoms of primary restless legs syndrome

Received 19 August 2008 ,Revised 5 November 2008 ,Accepted 6 November 2008.

References 

  1. Trenkwalder C, Paulus W. Why do restless legs occur at rest? Pathophysiology of neuronal structures in RLS. Neurophysiology of RLS (part 2). Clin Neurophysiol. 2004;115:1975–1988
  2. Montplaisir J, Boucher S, Nicolas A, et al. Immobilization tests and periodic leg movements in sleep for the diagnosis of restless leg syndrome. Mov Disord. 1998;13:324–329
  3. Tergau F, Wischer S, Paulus W. Motor system excitability in patients with restless legs syndrome. Neurology. 1999;52:1060–1063
  4. Ruottinen HM, Partinen M, Hublin C, et al. An FDOPA PET study in patients with periodic limb movement disorder and restless legs syndrome. Neurology. 2000;54:502–504
  5. Unrath A, Juengling FD, Schork M, Kassubeck J. Cortical grey matter alterations in idiopathic restless legs syndrome: an optimized voxel-based morphometry study. Mov Disord. 2007;22:1751–1756
  6. Pfurtscheller G, Lopes da Silva FH. Event-related EEG/MEG synchronization and desynchronization: basic principles. Clin Neurophysiol. 1999;110:1842–1857
  7. Pfurtscheller G, Stancak A, Neuper C. Post-movement beta synchronization. A correlate of an idling motor area?. Electroencephalogr Clin Neurophysiol. 1996;98:281–293
  8. Cassim F, et al. Does post-movement beta synchronization reflect an idling motor cortex?. Neuroreport. 2001;12:3859–3863
  9. Reyns N, Houdayer E, Bourriez JL, Blond S, Derambure P. Post-movement beta synchronization in subjects presenting with sensory deafferentation. Clin Neurophysiol. 2008;119:1335–1345
  10. Walters AS, LeBrocq C, Dhar A, et al. Validation of the international restless legs syndrome study group rating scale for restless legs syndrome. Sleep Med. 2003;4:121–132
  11. Michaud M, Poirier G, Lavigne G, et al. Restless legs syndrome: scoring criteria for leg movements recorded during the suggested immobilization test. Sleep Med. 2001;2:317–321
  12. ASDA. Atlas and scoring rules – recording and scoring leg movements: atlas task force of the American Sleep Disorders Association. Sleep 1993;16:748–59.
  13. Conover WJ, Iman RL. Analysis of covariance using the rank transformation. Biometrics. 1982;38:715–724
  14. Neuper C, Pfurtscheller G. Motor imagery and ERD. In:  Pfurtscheller G,  Lopes da Silva FHŽ editor. Event-related desynchronization. Handbook of electroencephalography and clinical neurophysiology. vol. 6:Amsterdam: Elsevier; 1999;p. 303–325[Revised ed.]
  15. Provini AF, Vetrugno R, Meletti S, et al. Motor pattern of periodic limb movements during sleep. Neurology. 2001;57:300–304
  16. Trenkwalder C, Bucher SF, Oertel WH, et al. Bereitschaftspotential in idiopathic and symptomatic restless legs syndrome. Electroenceph Clin Neurophysiol. 1993;89:95
  17. Rau C, Hummel F, Gerloff C. Cortical involvement in the generation of “involuntary” movements in restless legs syndrome. Neurology. 2004;62:998–1000
  18. Houdayer E, Labyt E, Cassim F, Bourriez JL, Derambure P. Relationship between event-related beta synchronization and afferent inputs: analysis of finger movement and peripheral nerve stimulations. Clin Neurophysiol. 2006;117:628–636
  19. Kutukcu Y, Dogruer E, Yetkin S, Ozgen F, Vural O, Aydin H. Evaluation of periodic leg movements and associated transcranial magnetic stimulation parameters in restless legs syndrome. Muscle Nerve. 2006;33:133–137
  20. Quatrale R, Manconi M, Gastaldo E, et al. Neurophysiological study of corticomotor pathways in restless legs syndrome. Clin Neurophysiol. 2003;114:1638–1645
  21. Schober T, Wenzel K, Feichtinger M, et al. Restless legs syndrome: changes of induced electroencephalographic beta oscillations-an ERD/ERS study. Sleep. 2004;27:147–150
  22. Defebvre L, Bourriez JL, Destée A, Guieu JD. Movement related desynchronisation pattern preceding voluntary movement in untreated Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1996;60:307–312
  23. Labyt E, Devos D, Bourriez JL, et al. Motor preparation is more impaired in Parkinson’s disease when sensorimotor integration is involved. Clin Neurophysiol. 2003;114:2423–2433
  24. Devos D, Labyt E, Derambure P, et al. Effect of L-Dopa on the pattern of movement-related (de)synchronisation in advanced Parkinson’s disease. Neurophysiol Clin. 2003;33:203–212
  25. Ondo WG, He Y, Rajasekaran S, Le WD. Clinical correlates of 6-hydroxydopamine injections into A11 dopaminergic neurons in rats: a possible model for restless legs syndrome. Mov Disord. 2000;15:154–158
  26. Zhao H, Zhu W, Pan T, et al. Spinal cord dopamine receptor expression and function in mice with 6-OHDA lesion of the A11 nucleus and dietary iron deprivation. J Neurosci Res. 2007;85:1065–1076

PII: S1389-9457(09)00070-7

doi: 10.1016/j.sleep.2008.11.008

Sleep Medicine
Volume 10, Issue 10 , Pages 1090-1096 , December 2009