Sleep Medicine
Volume 10, Issue 4 , Pages 494-496 , April 2009

Dopamine dysregulation syndrome in a patient with restless legs syndrome

  • Smaranda Leu-Semenescu

      Affiliations

    • Sleep Disorders Unit, Pitié-Salpêtrière Hospital, AP-HP, Paris, France
    • Corresponding Author InformationCorresponding author. Address: Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, 47-83 Boulevard de l’Hôpital, 75651 Paris Cedex 13, France. Tel.: +33 (1) 42167702; fax: +33 (1) 42167700.
    • ,
  • Elias Karroum

      Affiliations

    • Sleep Disorders Unit, Pitié-Salpêtrière Hospital, AP-HP, Paris, France
    • Paris 6 University, Paris, France
    • ,
  • Agnès Brion

      Affiliations

    • Sleep Disorders Unit, Pitié-Salpêtrière Hospital, AP-HP, Paris, France
    • ,
  • Eric Konofal

      Affiliations

    • Sleep Disorders Unit, Pitié-Salpêtrière Hospital, AP-HP, Paris, France
    • Paris 6 University, Paris, France
    • ,
  • Isabelle Arnulf

      Affiliations

    • Sleep Disorders Unit, Pitié-Salpêtrière Hospital, AP-HP, Paris, France
    • Paris 6 University, Paris, France

Received 24 September 2008 ,Revised 19 December 2008 ,Accepted 29 December 2008.

References 

  1. Spanagel R, Heiling M. Addiction and its brain science. Addiction. 2005;100:1813–1822
  2. Koepp MJ, Gunn RN, Lawrence AD, Cunningham VJ, Dagher A, Jones T. Evidence for striatal dopamine release during a video game. Nature. 1998;393:266–268
  3. Lawrence AD, Evans AH, Lees AJ. Compulsive use of dopamine replacement therapy in Parkinson’s disease: reward systems gone awry?. Lancet Neurol. 2003;2:595–604
  4. Trenkwalder C, Paulus W, Walter AS. The restless legs syndrome. Lancet Neurol. 2005;4:465–475
  5. Walters AS, LeBrocq C, Dhar A, Hening W, Rosen R, Allen RP, et al. International restless legs syndrome study group. Validation of the international restless legs syndrome study group rating scale for restless legs syndrome. Sleep Med. 2003;4:121–132
  6. Whiteside SP, Lynam DR. The five factor model and impulsivity: using a structural model of personality to understand impulsivity. Pers Indivi Differ. 2001;30:669–689
  7. Jenner P. Molecular mechanisms of L-DOPA-induced dyskinesia. Nat Rev Neurosci. 2008;9:665–677
  8. Tippmann-Peikert M, Park JG, Boeve BF, Shepard JW, Silber MH. Pathologic gambling in patients with restless legs syndrome treated with dopaminergic agonists. Neurology. 2007;68:301–303
  9. Ondo WG, Lai D. Predictors of impulsivity and reward seeking behavior with dopamine agonists. Parkinsonism Relat Disord. 2008;14:28–32
  10. Driver-Dunckley E, Samanta J, Stacy M. Pathological gambling associated with dopamine agonist therapy in Parkinson’s disease. Neurology. 2003;61:422–423

PII: S1389-9457(09)00051-3

doi: 10.1016/j.sleep.2008.12.010

Sleep Medicine
Volume 10, Issue 4 , Pages 494-496 , April 2009

Article Tools

* Image Usage & Resolution