Sleep Medicine
Volume 10, Issue 4 , Pages 405-406 , April 2009

Xyrem® safety: The debate continues

Received 23 January 2009 ,Accepted 2 February 2009.

References 

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  2. Elian AA. Determination of endogenous gamma-hydroxybutyric acid (GHB) levels in antemortem urine and blood. Forensic Sci Int. 2002;128:120–122
  3. Fieler EL, Coleman DE, Baselt RC. Gamma-hydroxybutyrate concentrations in pre- and postmortem blood and urine. Clin Chem. 1998;44:692
  4. Kintz P, Villain M, Cirimele V, Ludes B. GHB in postmortem toxicology. Discrimination between endogenous production from exposure using multiple specimens. Forensic Sci Int. 2004;143:177–181
  5. Elliott SP. Further evidence for the presence of GHB in postmortem biological fluid: implications for the interpretation of findings. J Anal Toxicol. 2004;28:20–26
  6. Ray WA, Chung CP, Murray KT, Hall K, Stein CM. Atypical antipsychotic drugs and the risk of sudden cardiac death. New Eng J Med. 2009;360:225–235
  7. Fuller DE, Hornfeldt CS, Kelloway JS, Stahl PJ, Anderson TF. The Xyrem® risk management program. Drug Safety. 2004;27:1
  8. Bronstein AC, Spyker DA, Cantilena LR, Green JL, et al. 2007 Annual report of the American association of poison control centers’ national poison data system (NPDS): 25th annual report. Clin Toxicol 2008;46:10,927–1057.
  9. George C, Feldman N. Effects of sodium oxybate (Xyrem®) on sleep-disordered breathing. Sleep Med. 2006;7:S73
  10. Seeck-Hirschner M, Baier PC, von Freier A, Aldenhoff J, Göder R. Increase in sleep-related breathing disturbances after treatment with sodium oxybate in patients with narcolepsy and mild obstructive sleep apnea syndrome: two case reports. Sleep Med. 2009;10:154–155
  11. Xyrem® prescribing information. Palo Alto, CA 94304: Jazz Pharmaceuticals, Inc.; 2005.

PII: S1389-9457(09)00041-0

doi: 10.1016/j.sleep.2009.02.002

Sleep Medicine
Volume 10, Issue 4 , Pages 405-406 , April 2009