Sleep Medicine
Volume 10, Issue 10 , Pages 1073-1074 , December 2009

Patho-physiology of restless legs syndrome: A very tedious puzzle!

  • Anna Scalise

      Affiliations

    • Corresponding Author InformationTel.: +39 0432552565; fax: +39 0432552719.

Received 29 January 2009 ,Accepted 10 February 2009.

References 

  1. Paulus W, Dowling P, Rijsman R, Stiasny-Kolster K, Trenkwalder C. Update of the pathophysiology of the restless-legs-syndrome. Mov Disord. 2007;22(Suppl. 18):S431–S439[Review]
  2. Barrière G, Cazalets JR, Bioulac B, Tison F, Ghorayeb I. The restless legs syndrome. Prog Neurobiol. 2005;77(3):139–165[Epub 2005 Nov 21. Review]
  3. Entezari-Taher M, Singleton JR, Jones CR, Meekins G, Petajan JH, Smith AG. Change in excitability of motor cortical circuitry in primary restless legs syndrome. Neurology. 1999;53:1201–1205
  4. Tergau F, Wischer S, Paulus W. Motor system excitability in patients with restless legs syndrome. Neurology. 1999;52:1060
  5. Quatrale R, Manconi M, Gastaldo E, et al. Neurophysiological study of corticomotor pathways in restless legs syndrome. Clin Neurophysiol. 2003;114:1638–1645
  6. Stiasny-Kolster K, Haeske H, Tergau F, Muller HH, Braune HJ, Oertel WH. Cortical silent period is shortened in restless legs syndrome independently from circadian rhythm. Suppl Clin Neurophysiol. 2003;56:381–389
  7. Scalise A, Pittaro-Cadore I, Gigli GL. Motor cortex excitability in restless legs syndrome. Sleep Med. 2004;5:393–396
  8. Scalise A, Pittaro-Cadore I, Golob EJ, Gigli GL. Absence of postexercise and delayed facilitation of motor cortex excitability in restless legs syndrome: evidence of altered cortical plasticity?. Sleep. 2006;29(6):770–775
  9. Rijsman RM, Stam CJ, de Weerd AW. Abnormal H-reflexes in periodic limb movement disorder; impact on understanding the pathophysiology of the disorder. Clin Neurophysiol. 2005;6(1):204–210
  10. Centonze D, Picconi B, Gubellini P, Bernardi G, Calabresi P. Dopaminergic control of synaptic plasticity in the dorsal striatum. Eur J Neurosci. 2001;13:1071–1077
  11. Bruel-Jungerman E, Davis S, Laroche S. Brain plasticity mechanisms and memory: a party of four. Neuroscientist. 2007;13(5):492–505[Review]
  12. Flöel A, Breitenstein C, Hummel F, Celnik P, Gingert C, Sawaki L, et al. Dopaminergic influences on formation of a motor memory. Ann Neurol. 2005;58(1):121–130
  13. Jay TM. Dopamine: a potential substrate for synaptic plasticity and memory mechanisms. Prog Neurobiol. 2003;69(6):375–390[Review]
  14. Calabresi P, Picconi P, Parnetti L, Di Filippo M. A convergent model for cognitive dysfunctions in Parkinson’s disease: the critical dopamine–acetylcholine synaptic balance. Lancet Neurol. 2006;5(11):974–983[Review]
  15. Nardone R, Ausserer H, Bratti A, et al. Cabergoline reverses cortical hyperexcitability in patients with restless legs syndrome. Acta Neurol Scand. 2006;114(4):244–249
  16. Kutukcu Y, Dogruer E, Yetkin S, Ozgen F, Vural O, Aydin H. Evaluation of periodic leg movements and associated transcranial magnetic stimulation parameters in restless legs syndrome. Muscle Nerve. 2006;33(1):133–137
  17. Gosler A, Liepert J. Influence of Carbergoline on motor excitability in patients with restless legs syndrome. J Clin Neurophysiol. 2007;24:456–460
  18. Rizzo V, Aricò I, Mastroeni C, Morgante F, Giovanna L, Girlanda P, Silvestri R, Quartarone A. Dopamine agonists restore cortical plasticity in patients with idiopathic restless legs syndrome. Mov Disord. 2008 Dec 31. [Epub ahead of print].
  19. Bara-Jimenez W, Aksu M, Graham B, Sato S, Hallett M. Periodic limb movements in sleep: state-dependent excitability of the spinal flexor reflex. Neurology. 2000;54(8):1609–1616
  20. Tyvaert L, Houdayer E, Devanne H, Bourriez JL, Derambure P, Monaca C. Cortical involvement in the sensory and motor symptoms of primary restless legs syndrome. Sleep Med. 2009;10:1090–1096

PII: S1389-9457(09)00040-9

doi: 10.1016/j.sleep.2009.02.001

Sleep Medicine
Volume 10, Issue 10 , Pages 1073-1074 , December 2009