Sleep Medicine
Volume 10, Issue 3 , Pages 279-286 , March 2009

Is usage of hypnotics associated with mortality?

  • Lena Mallon

      Affiliations

    • Department of Neuroscience, Psychiatry, Uppsala University, University Hospital, SE-75185 Uppsala, Sweden
    • Corresponding Author InformationCorresponding author. Tel.: +46 225 494400; fax: +46 225 494413.
    • ,
  • Jan-Erik Broman

      Affiliations

    • Department of Neuroscience, Psychiatry, Uppsala University, University Hospital, SE-75185 Uppsala, Sweden
    • ,
  • Jerker Hetta

      Affiliations

    • Department of Clinical Neuroscience, Psychiatry, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden

Received 6 November 2008 ,Revised 19 December 2008 ,Accepted 23 December 2008.

References 

  1. Kripke DF, Simons RN, Garfinkel L, Hammond EC. Short and long sleep and sleeping pills. Is increased mortality associated?. Arch Gen Psychiatry. 1979;36:103–116
  2. Qureshi AI, Giles WH, Croft JB, Bliwise DL. Habitual sleep patterns and risk for stroke and coronary heart disease: a 10-year follow-up from NHANES I. Neurology. 1997;48:904–911
  3. Pollak CP, Perlick D, Linsner JP, Wenston J, Hsieh F. Sleep problems in the community elderly as predictors of death and nursing home placement. J Community Health. 1990;15:123–135
  4. Kripke D, Garfinkel L, Wingard D, Klauber M, Marler M. Mortality associated with sleep duration and insomnia. Arch Gen Psychiatry. 2002;59:131–136
  5. Patel SR, Ayas NT, Malhotra MR, White DP, Schernhammer ES, Speizer FE, et al. A prospective study of sleep duration and mortality risk in women. Sleep. 2004;27:440–444
  6. Kojima M, Wakai K, Kawamura T, Tamakoshi A, Aoki R, Lin Y, et al. Sleep patterns and total mortality: a 12-year follow-up study in Japan. J Epidemiol. 2000;10:87–93
  7. Heslop P, Smith GD, Metcalfe C, Macleod J, Hart C. Sleep duration and mortality: the effect of short or long sleep duration on cardiovascular and all-cause mortality in working men and women. Sleep Med. 2002;3:305–314
  8. Amagai Y, Ishikawa S, Gotoh T, Doi Y, Kayaba K, Nakamura Y, et al. Sleep duration and mortality in Japan: the jichi medical school cohort study. J Epidemiol. 2004;14:124–128
  9. Mallon L, Broman JE, Hetta J. Sleep complaints predict coronary artery disease mortality in males: a 12-year follow-up study of a middle-aged Swedish population. J Int Med. 2002;251:207–216
  10. Tamakoshi A, Ohno Y JACC Study Group. Self-reported sleep duration as a predictor of all-cause mortality: results from the JACC study, Japan. Sleep. 2004;27:51–54
  11. Burazeri G, Goflin J, Kark JD. Over 8h of sleep—marker of increased mortality in Mediterranean population: follow-up population study. Croat Med J. 2003;44:193–198
  12. Hublin C, Partinen M, Koskenvuo M, Kaprio J. Sleep and mortality: a population-based 22-year follow-up study. Sleep. 2007;30:1245–1253
  13. Rumble R, Morgan K. Hypnotics, sleep, and mortality in elderly people. J Am Geriatr Soc. 1992;40:787–791
  14. Althuis MD, Fredman L, Langenberg PW, Magaziner J. The relationship between insomnia and mortality among community-dwelling older women. J Am Geriatr Soc. 1998;46:1270–1273
  15. Phillips B, Mannino D. Does insomnia kill?. Sleep. 2005;28:965–971
  16. Kripke DF, Klauber MR, Wingard DL, Fell RL, Assmus JD, Garfinkel L. Mortality hazard associated with prescription hypnotics. Biol Psychiatry. 1998;43:687–693
  17. Hausken AM, Skurtveit S, Tverdal A. Use of anxiolyic or hypnotic drugs and total mortality in a general middle-aged population. Pharmacoepidemiol Drug Saf. 2007;16:913–918
  18. Ford DE, Kamerow DB. Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention?. JAMA. 1989;262:1479–1484
  19. Mallon L, Broman JE, Hetta J. Relationship between insomnia, depression and mortality: a 12-year follow-up of older adults in the community. Int Psychogeriatr. 2000;12:295–306
  20. Riemann D, Voderholzer U. Primary insomnia: a risk factor to develop depression?. J Affect Disord. 2003;76:255–259
  21. Liljenberg B, Almqvist M, Hetta J, Roos BE, Ågren H. The prevalence of insomnia: the importance of operationally defined criteria. Ann Clin Res. 1988;20:393–398
  22. Hetta J, Almqvist M, Ågren H, Hambert G, Liljenberg B, Roos BE. Prevalence of sleep disturbances and related symptoms in a middle-aged Swedish population. In:  Koella W,  Ruther E,  Schultz H editor. Sleep ´84. Stuttgart: Gustav Fischer Verlag; 1985;p. 373–376
  23. Liljenberg B, Almqvist M, Hetta J, Roos BE, Ågren H. Affective disturbances and insomnia. Eur J Psychiatry. 1989;3:91–98
  24. Broman JE, Lundh LG, Hetta J. Insufficient sleep in the general population. Neurophysiol Clin. 1996;26:30–39
  25. Mallon L, Broman JE, Hetta J. High incidence of diabetes in men with sleep complaints or short sleep duration: a 12-year follow-up study of a middle-aged population. Diabetes Care. 2005;28:2762–2767
  26. Allgulander C, Näsman P. Regular hypnotic drug treatment in a sample of 32, 679 Swedes: associations with somatic and mental health, inpatient psychiatric diagnosis and suicide, derived with automatic record-linkage. Psychosom Med. 1991;53:101–108
  27. Blennow G, Romelsjö A, Leifman H, Leifman A, Karlsson G. Seatives and hypnotics in Stockholm: social factors and kinds of use. Am J Public Health. 1994;84:242–246
  28. Kageyama T, Kabuto M, Nitta H, Kurokawa Y, Taira K, Suzuki S, et al. Prevalence of medically prescribed hypnotics among adult Japanese women in urban residential areas. Psychiatry Clin Neurosci. 1998;52:69–74
  29. Voss M, Nylen L, Floderus B, Diderichsen F, Terry PD. Unemployment and early cause-specific mortality: a study based on the Swedish twin registry. Am J Public Health. 2004;94:2155–2161
  30. Schade C, Jones E, Wittlin B. A 10-year review of the validity and clinical utility of depression screening. Psychiatr Serv. 1998;49:55–61
  31. McKenzie N, Marks I. Quick rating of depressed mood in patients with anxiety disorders. Br J Psychiatry. 1999;174:266–269
  32. Mallon L, Hetta J. One question approach to detect depression: a comparison between questionnaire and interview data in a community sample of older adults. Eur J Psychiatry. 2002;16:135–144
  33. Jansson-Fröjmark M, Linton SJ. The course of insomnia over one year: a longitudinal study in the general population in Sweden. Sleep. 2008;31:881–886
  34. Wulsin LR, Evans JC, Vasan RS, Murabito JM, Kelly-Hayes M, Benjamin EJ. Depressive symptoms, coronary heart disease, and overall mortality in the Framingham heart study. Psychosom Med. 2005;67:697–702
  35. Mykletun A, Bjerkeset O, Dewey M, Prince M, Overland S, Stewart R. Anxiety, depression, and cause-specific mortality: the HUNT study. Psychosom Med. 2007;69:323–331
  36. Kripke DF. Greater incidence of depression with hypnotic use than placebo. BMC. 2007;7:42
  37. Neckelmann D, Mykletun A, Dahl MD. Chronic insomnia as a risk factor for developing anxiety and depression. Sleep. 2007;30:873–880
  38. Gonda X, Fountoulakis KN, Kaprinis G, Rihmer Z. Prediction and prevention of suicide in patients with unipolar depression and anxiety. Ann Gen Psychiatry. 2007;6:23
  39. Rihmer Z. Suicide risk in mood disorders. Curr Opin Psychiatry. 2007;20:17–22
  40. Neutel CI, Patten SB. Risk of suicide attempts after benzodiazepine and/or antidepressant use. Ann Epidemiol. 1997;7:568–574
  41. Drummer OH. Benzodiazepines—effect on human performance and behaviour. Forensic Sci Rev. 2002;14:2–14
  42. Kripke DF. Possibility that certain hypnotics might cause cancer in the skin. J Sleep Res. 2008;17:245–250
  43. Drug sales statistics. Internal database at National Corporation of Swedish Pharmacies (Apotekets AB).

PII: S1389-9457(09)00002-1

doi: 10.1016/j.sleep.2008.12.004

Sleep Medicine
Volume 10, Issue 3 , Pages 279-286 , March 2009

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