Sleep Medicine
Volume 10, Issue 9 , Pages 976-981 , October 2009

The four diagnostic criteria for Restless Legs Syndrome are unable to exclude confounding conditions (“mimics”)

  • Wayne A. Hening

      Affiliations

    • UMDNJ-RW Johnson Medical Center, New Brunswick, NJ, USA
  • ,
  • Richard P. Allen

      Affiliations

    • Johns Hopkins University, Baltimore, MD, USA
    • Corresponding Author InformationCorresponding author. Address: Asthma and Allergy, Rm 1B75B, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA. Tel.: +1 410 550 2609; fax: +1 410 550 3364.
  • ,
  • Mystinna Washburn

      Affiliations

    • Johns Hopkins University, Baltimore, MD, USA
  • ,
  • Suzanne R. Lesage

      Affiliations

    • University of Maryland Medical Center, Baltimore, MD, USA
  • ,
  • Christopher J. Earley

      Affiliations

    • Johns Hopkins University, Baltimore, MD, USA

Received 2 March 2008 ,Revised 18 September 2008 ,Accepted 22 September 2008.

References 

  1. Berger K, Luedemann J, Trenkwalder C, John U, Kessler C. Sex and the risk of restless legs syndrome in the general population. Arch Intern Med. 2004;164:196–202
  2. Allen RP, Walters AS, Montplaisir J, et al. Restless Legs Syndrome Prevalence and impact: REST general population study. Arch Intern Med. 2005;165:1286–1292
  3. Bjorvatn B, Leissner L, Ulfberg J, et al. Prevalence, severity and risk factors of restless legs syndrome in the general adult population in two Scandinavian countries. Sleep Med. 2005;6:307–312
  4. Vogl FD, Pichler I, Adel S, et al. Restless legs syndrome: epidemiological and clinicogenetic study in a South Tyrolean population isolate. Mov Disord. 2006;21:1189–1195
  5. Cho YW, Shin WC, Yun CH, et al. Eidemiology of restless legs syndrome in Korean adults. Sleep. 2008;31:219–223
  6. Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003;4:101–119
  7. Rothdach AJ, Trenkwalder C, Haberstock J, Keil U, Berger K. Prevalence and risk factors of RLS in an elderly population: the MEMO study. Memory and morbidity in Augsburg elderly. Neurology. 2000;54:1064–1068
  8. Berger K, von Eckardstein A, Trenkwalder C, Rothdach A, Junker R, Weiland SK. Iron metabolism and the risk of Restless Legs Syndrome in an elderly general population – The MEMO-Study. Memory and morbidity. J Neurol. 2002;249:1195–1199
  9. Hening WA, Allen RP, Thanner S, et al. The Johns Hopkins telephone diagnostic interview for the restless legs syndrome: preliminary investigation for validation in a multi-center patient and control population. Sleep Med. 2003;4:137–141
  10. Hening WA, Allen RP, Washburn M, Lesage S, Earley CJ. Validation of the Hopkins telephone diagnostic interview for restless legs syndrome. Sleep Med. 2008;9(3):283–289
  11. The International Restless Legs Syndrome Study Group. Towards a better definition of the Restless Legs Syndrome. Mov Disord. 1995;10:634–642
  12. Mathias RA, Hening W, Washburn M, et al. Segregation analysis of restless legs syndrome: possible evidence for a major gene in a family study using blinded diagnoses. Hum Hered. 2006;62:157–164
  13. Walters AS, Hickey K, Maltzman J, et al. A questionnaire study of 138 patients with restless legs syndrome: the ’Night-Walkers’ survey. Neurology. 1996;46:92–95
  14. Hogl B, Kiechl S, Willeit J, et al. Restless legs syndrome: a community-based study of prevalence, severity, and risk factors. Neurology. 2005;64:1920–1924
  15. Mizuno S, Miyaoka T, Inagaki T, Horiguchi J. Prevalence of restless legs syndrome in non-institutionalized Japanese elderly. Psychiatry Clin Neurosci. 2005;59:461–465
  16. Earley CJ. Clinical practice. Restless legs syndrome. N Engl J Med. 2003;348:2103–2109
  17. Littner MR, Kushida C, Anderson WM, et al. Practice parameters for the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder. Sleep. 2004;27:557–559
  18. Fulda S, Wetter TC. Emerging drugs for restless legs syndrome. Expert Opin Emerg Drugs. 2005;10:537–552
  19. Michaud M, Paquet J, Lavigne G, Desautels A, Montplaisir J. Sleep laboratory diagnosis of restless legs syndrome. Eur Neurol. 2002;48:108–113
  20. Stiasny-Kolster K, Kohnen R, Moller JC, Trenkwalder C, Oertel WH. Validation of the “L-DOPA test” for diagnosis of restless legs syndrome. Mov Disord. 2006;21:1333–1339
  21. Bassetti CL, Mauerhofer D, Gugger M, Mathis J, Hess CW. Restless legs syndrome: a clinical study of 55 patients. Eur Neurol. 2001;45:67–74
  22. Hening W, Walters AS, Allen RP, Montplaisir J, Myers A, Ferini-Strambi L. Impact, diagnosis and treatment of restless legs syndrome (RLS) in a primary care population: the REST (RLS epidemiology, symptoms, and treatment) primary care study. Sleep Med. 2004;5:237–246
  23. Allen RP, Burchell BJ, MacDonald B, Hening WA, Earley CJ. Validation of the self-completed Cambrdige-Hopkins RLS questionnaire (CH-RLSq) for ascertainement of restless legs syndrome in a population survey. Sleep Med [in press]. doi:10.1016/j.sleep.2008.10.007.

PII: S1389-9457(08)00361-4

doi: 10.1016/j.sleep.2008.09.015

Sleep Medicine
Volume 10, Issue 9 , Pages 976-981 , October 2009