Sleep Medicine
Volume 10, Issue 3 , Pages 361-367 , March 2009

Hyperviscosity as a possible cause of positive acoustic evoked potential findings in patients with sleep apnea: A dual electrophysiological and hemorheological study

  • István Bernáth

      Affiliations

    • Department of Sleep Disorders, State Health Center, 44 Robert K. krt, 1134 Budapest, Hungary
    • Corresponding Author InformationCorresponding author. Tel.: +361 212 1846; fax: +361 457 0981.
    • ,
  • Patrick McNamara

      Affiliations

    • Department of Neurology, Boston University School of Medicine and VA New England, Healthcare System, 150 South Huntington Avenue, Boston, MA 02130, USA
    • ,
  • Nóra Szternák

      Affiliations

    • Department of Sleep Disorders, State Health Center, 44 Robert K. krt, 1134 Budapest, Hungary
    • ,
  • Zoltán Szakács

      Affiliations

    • Department of Sleep Disorders, State Health Center, 44 Robert K. krt, 1134 Budapest, Hungary
    • ,
  • Péter Köves

      Affiliations

    • Department of Sleep Disorders, State Health Center, 44 Robert K. krt, 1134 Budapest, Hungary
    • ,
  • Attila Terray-Horváth

      Affiliations

    • Department of Sleep Disorders, State Health Center, 44 Robert K. krt, 1134 Budapest, Hungary
    • ,
  • Zsuzsanna Vida

      Affiliations

    • Department of Sleep Disorders, State Health Center, 44 Robert K. krt, 1134 Budapest, Hungary

Received 6 October 2007 ,Revised 30 January 2008 ,Accepted 16 March 2008.

References 

  1. Yaggl HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl Med. 2005;353:2034–2041
  2. Chin K, Ohi M, Kita H, et al. Effects of NCPAP therapy on fibrinogen levels in obstructive sleep apnea syndrome. Am J Respir Crit Care Med. 1996;153:1972–1976
  3. Steiner S, Jax T, Evers S, Hennersdorf M, Schwalen A, Strauer BF. Altered blood rheology in obstructive sleep apnea as a mediator of cardiovascular risk. Cardiology. 2005;104:92–96
  4. Bernáth I, Pongrácz E, Köves P, Szakács Z. Effects of blood hyperviscosity on functional integrity in the brainstem: a brainstem evoked auditory potential study. Clin Hemorheol Microcirc. 2004;31:123–128
  5. Cimino A, Speciale R, Gallina S. Brain stem auditory evoked potentials in obstructive sleep apnea syndrome. Acta Otorhinolaryngol Ital. 1995;15(2 Suppl 47):15–17
  6. Muchnik C, Rubel Y, Zohar Y, Hildesheimer M. Auditory brainstem response in sleep apnea patients. J Basic Clin Physiol Pharmacol. 1995;6:139–148
  7. Snyderman NL, Johnson JT, Moller M, Thearle PB. Brainstem evoked potentials in adult sleep apnea. Ann Otol Rhinol Laryngol. 1982;91(6 Pt):597–598
  8. Wetmore SJ, Henderson C, Doshier NW, Milligan LB. Auditory brainstem response in obstructive sleep apnea. Laryngoscope. 1988;98:499–501
  9. Zeitlhofer J, Graf M, Mamoli B, Schlick W, Kummer F, Haber P. Neurophysiologic studies in Pickwickian syndrome. Nervenarzt. 1986;57:263–268
  10. Mosko SS, Pierce S, Holowach J, Sassin JF. Normal brainstem auditory evoked potentials recorded in sleep apneics during waking and as a function of arterial oxygen saturation during sleep. Electroencephalogr Clin Neurophysiol. 1981;51:477–482
  11. Schlegel J, Urban PP. Electrophysiological brain-stem diagnosis in patients with a pronounced obstructive sleep apnea syndrome. Dtsch Med Wochenschr. 1999;124:613–617
  12. Verma NP, Kapen S, King SD, Koshorek GJ. Bimodality electrophysiologic evaluation of brainstem in sleep apnea syndrome. Neurology. 1987;37:1036–1039
  13. Kotterba S, Rasche K. Acoustic evoked potentials (AEP) in obstructive sleep apnea syndrome. Pneumonologie. 1996;50:924–926
  14. Rechtschafen A, Kales A. A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Los Angeles: UCLA Brain Information Service, Brain Research Institute; 1968;
  15. Kita H, Ohi M, Chin K, Noguchi T, et al. The nocturnal secretion of cardiac natriuretic peptides during obstructive sleep apnea and its response to therapy with nasal continuous positive airway pressure. J Sleep Res. 1998;7:199–207
  16. Lin CC, Tsan KW, Lin CY. Plasma levels of atrial natriuretic factor in moderate to severe obstructive sleep apnea syndrome. Sleep. 1993;16:37–39
  17. Baruzzi A, Riva R, Cirignotta F, Zucconi M, Capelli M, Lugaresi E. Atrial natriuretic peptide and catecholamines in obstructive sleep apnea syndrome. Sleep. 1991;14:83–86
  18. Nobili L, Schiavi G, Bozano E, Carli F, Ferillo F, Nobili F. Morning increase of whole blood viscosity in obstructive sleep apnea syndrome. Clin Hemorhol Microcirc. 2000;22:21–27
  19. Reinhart WH, Oswald J, Walter R, Kuhn M. Blood viscosity and platelet function in patients with obstructive sleep apnea syndrome treated with nasal continuous positive airway pressure. Clin Hemorheol Microcirc. 2002;27:201–207
  20. Wende S, Nakayama N, Schwerdtfyn P. The internal auditory artery. J Neurol. 1975;210:21–31
  21. Sohmer M, Gafni G, Havatselet G. Persistence of auditory nerve response and absence of brain stem response in severe cerebral ischemia. Electroencephalogr Clin Neurophysiol. 1984;58:56–72
  22. Callejo GF, Albroch OM, Ventura MA, Algarra J. Neurosensory sudden deafness, blood hyperviscosity syndrome, and diabetes mellitus. Acta Otorrinolariongol Esp. 2002;53:221–224
  23. Chae SW, Cho JH, Lee JH, Kang HJ, Hwang SJ. Sudden hearing loss in chronic myelogenous leukaemia implicating the hyperviscosity syndrome. J Laryngol Otol. 2002;116:291–293
  24. Glacet-Bernard A, Roquet W, Coste A, Peynegre R, Coscas G, Soubrane G. Central retinal vein occlusion and sudden deafness: a possible common pathogenesis. Eur J Ophthalmol. 2001;11:197–199
  25. Syms MJ, Arcila ME, Holte MR. Waldenstrom’s macroglobulinemia and sensorineural hearing loss. Am J Otolaryngol. 2001;22:349–353
  26. Tsai CC, Huang CB, Sheen JM, Wei HH, Hsiao CC. Sudden hearing loss as the initial manifestation of chronic myeloid leukemia in a child. Chang Gung Med J. 2004;27:629–633

PII: S1389-9457(08)00099-3

doi: 10.1016/j.sleep.2008.03.012

Sleep Medicine
Volume 10, Issue 3 , Pages 361-367 , March 2009

Article Tools