Sleep Medicine
Volume 9, Issue 8 , Pages 890-893 , December 2008

Comparison of obstructive sleep apnea patients with and without leg edema

  • Imran Iftikhar

      Affiliations

    • Department of Internal Medicine, Fairview Hospital, Cleveland Clinic System, Cleveland, OH, United States
    • ,
  • Mansoor Ahmed

      Affiliations

    • Southwest Cleveland Sleep Center, Middleburg Heights, OH, United States
    • ,
  • Shannon Tarr

      Affiliations

    • Department of Surgery, Fairview Hospital, Cleveland Clinic System, Cleveland, OH, United States
    • ,
  • Stephen J. Zyzanski

      Affiliations

    • Department of Family Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, United States
    • ,
  • Robert P. Blankfield

      Affiliations

    • Department of Family Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, United States
    • University Hospitals Medical Practice, Berea, OH, United States
    • Corresponding Author InformationCorresponding author. Address: Berea Health Center, 201 Front Street, Suite 101, Berea, OH 44017, United States. Tel.: +1 440 243 7299; fax: +1 440 243 0651.

Received 28 April 2007 ,Revised 26 September 2007 ,Accepted 5 October 2007.

References 

  1. Blankfield RP, Ahmed M, Zyzanski SJ. Idiopathic edema is associated with obstructive sleep apnea in women. Sleep Med. 2004;5(6):583–587
  2. Blankfield RP, Ahmed M, Zyzanski SJ. Effect of nasal continuous positive airway pressure on edema in patients with obstructive sleep apnea. Sleep Med. 2004;5(6):589–592
  3. Bradley TD, Rutherford R, Grossman RF, Lue F, Zamel N, Moldofsky H. Role of daytime hypoxemia in the pathogenesis of right heart failure in the obstructive sleep apnea syndrome. Am Rev Resp Dis. 1985;131:835–839
  4. Whyte KF, Douglas NJ. Peripheral edema in the sleep apnea/hypopnea syndrome. Sleep. 1991;14:354–356
  5. Rechtschaffen A, Kales A. A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Bethesda, MD: US Government Printing Office 1968; NIH publication no. 204.
  6. Strohl KP, Redline S. Recognition of obstructive sleep apnea. Am J Resp Crit Care Med. 1996;154:279–289
  7. Wiegand L, Zwillich CW. Obstructive sleep apnea. Dis Mon. 1994;40:199–251
  8. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991;14(6):540–545
  9. Shahar E, Whitney CW, Redline S, et al. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Resp Crit Care Med. 2001;163:19–25
  10. Marin JM, Carrizo SJ, Vicente E, Agusti AG. Long-term cardiovascular outcomes in men with obstructive sleep-a5. Strohl KP, Redline S. Recognition of obstructive sleep apnea. Am J Resp Crit Care Med. 1996;154:279–289
  11. Nieto FJ, Young TB, Lind BK, et al. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. JAMA. 2000;283(14):1829–1836
  12. Peppard PE, Young T, Paltza M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med. 2000;342:1378–1384
  13. Pepperrell JC, Ramdassingh-Dow S, Crosthwaite N, et al. Ambulatory blood pressure after therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomized parallel trial. Lancet. 2001;359:204–210
  14. Minemura H, Akashiba T, Yamamoto H, Akahoshi T, Kosaka N, Horie T. Acute effects of nasal continuous positive airway pressure o 24-hour blood pressure and catecholamines in patients with obstructive sleep apnea. Intern Med. 1998;37(12):1009–1013
  15. Ziegler MG, Nelesen R, Mills P, Ancoli-Israel S, Kennedy B, Dimsdale JE. Sleep apnea, norepinephrine-release rate, and daytime hypertension. Sleep. 1997;20(3):224–231
  16. Dimsdale JE, Coy T, Ziegler MG, Ancoli-Israel S, Clausen J. The effect of sleep apnea on plasma and urinary catecholamines. Sleep. 1995;18(5):377–381
  17. Klingelhöfer J, Hajak G, Sander D, Schulz-Varszegi M, Rüther E, Conrad B. Assessment of intracranial hemodynamics in sleep apnea syndrome. Stroke. 1992;23:1427–1433
  18. Gainer JL. Hypoxia and atherosclerosis: re-evaluation of an old hypothesis. Athersclerosis. 1987;68:263–266
  19. Wang TJ, Larson MG, Levy D, et al. Plasma natriuretic peptide levels and the risk of cardiovascular events and death. N Engl J Med. 2004;350:718–720
  20. Blankfield RP. Implications of calculated intravascular volume changes upon atherosclerotic cardiovascular disease. Clin Hemorheol Microcirc. 2008;38:75–81

☆ None of the authors has a financial interest or a conflict of interest regarding the subject matter of this study.

PII: S1389-9457(07)00442-X

doi: 10.1016/j.sleep.2007.10.019

Sleep Medicine
Volume 9, Issue 8 , Pages 890-893 , December 2008

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