Sleep quality in a family with hereditary parkinsonism (PARK6)

Tuin, I.; Voss, U.; Kessler, K.; Krakow, K.; Hilker, R.; Morales, B.; Steinmetz, H.; Auburger, G.

doi:10.1016/j.sleep.2007.07.004

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Volume 9, Issue 6 , Pages 684-688, August 2008

Sleep quality in a family with hereditary parkinsonism (PARK6)

I. Tuin
- Department of Psychiatry, J.W. Goethe University, Frankfurt am Main, Germany
- Corresponding authors. Tel.: +49 7896717; fax: +49 798 23457.
- These authors have contributed equally to the manuscript and are named in alphabetical order.
U. Voss
- Department of Psychology, J.W. Goethe University, Frankfurt am Main, Germany
- Corresponding authors. Tel.: +49 7896717; fax: +49 798 23457.
- These authors have contributed equally to the manuscript and are named in alphabetical order.
K. Kessler
- Department of Neurology, J.W. Goethe University, Frankfurt am Main, Germany
K. Krakow
- Department of Neurology, J.W. Goethe University, Frankfurt am Main, Germany
R. Hilker
- Department of Neurology, J.W. Goethe University, Frankfurt am Main, Germany
B. Morales
- Neurological Clinic of the University Hospital ‘‘San Cecilio’’, Granada, Spain
H. Steinmetz
- Department of Neurology, J.W. Goethe University, Frankfurt am Main, Germany
G. Auburger
- Department of Neurology, J.W. Goethe University, Frankfurt am Main, Germany

Received 20 February 2007; received in revised form 9 July 2007; accepted 10 July 2007.

Abstract

Objectives

The autosomal recessive disorder PARK6 manifests as early-onset Parkinson’s disease (PD) with a particularly mild progression. PARK6 is of particular scientific interest, since it is caused by loss-of-function mutations in the mitochondrial protein kinase PINK1 and may thus serve as a model for oxidative damage in PD and in other basal ganglia disorders. Sleep disturbances are very common in PD but have not yet been reported for PARK6 patients. The present study reports on sleep of a Spanish family with PARK6. Of the 5 siblings, 3 were homozygous and severely affected, and 2 were heterozygous and clinically asymptomatic. Research questions concerned possible differences in sleep recordings between homozygote and heterozygote siblings and similarities between PARK6 and sporadic PD sleep profiles.

Method

The data from detailed clinical interviews of the patients and their bedpartners are reported and compared with polysomnographic data from second-night recordings.

Conclusions

All siblings had good subjective and objective sleep quality. Restless legs syndrome and rapid eye movement (REM) sleep behaviour disorder (RBD) were not observed, suggesting that sleep disturbances are not commonly found in PARK6 patients. Good sleep quality and the absence of RBD might be a useful diagnostic guide in the differential diagnosis of sporadic PD versus PARK6.

Keywords: PARK6, Parkinsonism, Sleep, Sleep quality, RLS, RBD