Sleep Medicine
Volume 7, Issue 6 , Pages 480-485 , September 2006

Undiagnosed individuals with first-degree relatives with restless legs syndrome have increased periodic limb movements

  • Paul V. Birinyi

      Affiliations

    • Department of Neuroscience, Baltimore, The Johns Hopkins University School of Art and Sciences, MD, USA
    • ,
  • Richard P. Allen

      Affiliations

    • Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    • Corresponding Author InformationCorresponding author. Neurology and Sleep Medicine, Johns Hopkins University, Asthma and Allergy Bldg 1B76b, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA. Tel.: +1 410 550 1044; fax: +1 410 550 3364.
    • ,
  • Wayne Hening

      Affiliations

    • Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    • ,
  • Tinna Washburn

      Affiliations

    • Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    • ,
  • Suzanne Lesage

      Affiliations

    • Department of Neurology, School of Medicine, The University of Maryland, Baltimore, MD, USA
    • ,
  • Christopher J. Earley

      Affiliations

    • Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Received 25 January 2006 ,Revised 10 April 2006 ,Accepted 21 April 2006.

References 

  1. Allen RP, Picchietti D, Hening WA, et al. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003;4(2):101–119
  2. Montplaisir J, Boucher S, Poirier G, et al. Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: a study of 133 patients diagnosed with new standard criteria. Mov Disord. 1997;12(1):61–65
  3. Allen RP, Walters AS, Montplaisir J, et al. Restless legs syndrome prevalence and impact: REST general population study. Arch Intern Med. 2005;165(11):1286–1292
  4. Walters AS, Picchietti D, Hening W, Lazzarini A. Variable expressivity in familial restless legs syndrome. Arch Neurol. 1990;47(11):1219–1220
  5. Bonati MT, Ferini-Strambi L, Aridon P, et al. Autosomal dominant restless legs syndrome maps on chromosome 14q. Brain. 2003;126(Pt 6):1485–1492
  6. Chen S, Ondo WG, Rao S, et al. Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p. Am J Hum Genet. 2004;74(5):876–885
  7. Desautels A, Turecki G, Montplaisir J, et al. Identification of a major susceptibility locus for restless legs syndrome on chromosome 12q. Am J Hum Genet. 2001;69(6):1266–1270
  8. Allen RP, La Buda MC, Becker P, Earley CJ. Family history study of the restless legs syndrome. Sleep Med. 2002;3(3 Suppl.):S3–S7
  9. Winkelmann J, Muller-Myhsok B, Wittchen HU, et al. Complex segregation analysis of restless legs syndrome provides evidence for an autosomal dominant mode of inheritance in early age at onset families. Ann Neurol. 2002;52(3):297–302
  10. Allen RP, Earley CJ. Defining the phenotype of the restless legs syndrome (RLS) using age-of-symptom-onset. Sleep Med. 2000;1:11–19
  11. Sforza E, Johannes M, Claudio B. The PAM-RL ambulatory device for detection of periodic leg movements: a validation study. Sleep Med. 2005;6(5):407–413
  12. Hening W, Allen RP, Thanner S, et al. The Johns Hopkins telephone diagnostic interview for the restless legs syndrome: preliminary investigation for validation in a multi-center patient and control population. Sleep Med. 2003;4(2):137–141
  13. Yang C, White DP, Winkelman JW. Antidepressants and periodic leg movements of sleep. Biol Psychiatry. 2005;58(6):510–514
  14. Allen RP, Earley CJ. Validation of the Johns Hopkins restless legs severity scale. Sleep Med. 2001;2:239–242
  15. Walters AS, LeBrocq C, Dhar A, et al. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med. 2003;4(2):121–132

PII: S1389-9457(06)00116-X

doi: 10.1016/j.sleep.2006.04.003

Sleep Medicine
Volume 7, Issue 6 , Pages 480-485 , September 2006

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