Sleep Medicine
Volume 7, Issue 5 , Pages 424-430 , August 2006

Gender differences on polysomnographic findings in Greek subjects with obstructive sleep apnea syndrome

  • E. Vagiakis

      Affiliations

    • Critical Care and Pulmonary Services, Medical School, Sleep Disorders Center, Evangelismos Hospital, University of Athens, Athens, Greece
    • ,
  • F. Kapsimalis

      Affiliations

    • Sleep Laboratory, Respiratory Medicine Department, Henry Dunant Hospital, 107 Mesogeion Avenue, GR 115 26 Athens, Greece
    • Corresponding Author InformationCorresponding author. Tel.: +30 210 6972000; fax: +30 210 6972869.
    • ,
  • I. Lagogianni

      Affiliations

    • Critical Care and Pulmonary Services, Medical School, Sleep Disorders Center, Evangelismos Hospital, University of Athens, Athens, Greece
    • ,
  • H. Perraki

      Affiliations

    • Critical Care and Pulmonary Services, Medical School, Sleep Disorders Center, Evangelismos Hospital, University of Athens, Athens, Greece
    • ,
  • A. Minaritzoglou

      Affiliations

    • Critical Care and Pulmonary Services, Medical School, Sleep Disorders Center, Evangelismos Hospital, University of Athens, Athens, Greece
    • ,
  • K. Alexandropoulou

      Affiliations

    • Critical Care and Pulmonary Services, Medical School, Sleep Disorders Center, Evangelismos Hospital, University of Athens, Athens, Greece
    • ,
  • C. Roussos

      Affiliations

    • Critical Care and Pulmonary Services, Medical School, Sleep Disorders Center, Evangelismos Hospital, University of Athens, Athens, Greece
    • ,
  • M. Kryger

      Affiliations

    • Sleep Disorders Centre, St Boniface Hospital Research Center, University of Manitoba, Winnipeg, Man., Canada

Received 3 August 2005 ,Revised 27 December 2005 ,Accepted 30 December 2005.

References 

  1. Bassiri AG, Guilleminault C. Clinical features and evaluation of obstructive sleep apnea hypopnea syndrome. In:  Kryger M,  Roth T,  Dement W editor. Principles and practice of sleep medicine. 4th ed. Philadelphia, PA: Saunders; 2005;
  2. Chaudhary BA, Speir WA. Sleep apnea syndromes. South Med J. 1982;75:39–45
  3. Block AJ, Boysen PG, Wynne JW, Hunt LA. Sleep apnea, hypopnea and oxygen desaturation in normal subjects: a strong male predominance. N Engl J Med. 1979;300(10):513–517
  4. Young T, Palta M, Dempsey J, et al. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993;328(17):1230–1235
  5. Bixler E, Vgontzas A, Lin HM, et al. Prevalence of sleep disordered breathing in women. Effect of gender. Am J Respir Crit Care Med. 2001;163:608–613
  6. Kapsimalis F, Kryger M. Gender and obstructive sleep apnea syndrome, part 1: clinical features. Sleep. 2002;25(4):412–419
  7. Hoffstein V, Szalai P. Predictive value of clinical features in diagnosing obstructive sleep apnea. Sleep. 1993;16:118–122
  8. Young T, Hutton R, Finn L, et al. The gender bias in sleep apnea syndrome. Are women missed because they have different symptoms?. Arch Intern Med. 1996;156:2425–2451
  9. Redline S, Kump K, Tishler P, et al. Gender differences in sleep disordered breathing in a community-based sample. Am J Respir Crit Care Med. 1994;149:722–726
  10. Smith R, Ronald J, Delaive K, et al. What are obstructive apnea patients being treated for prior to this diagnosis?. Chest. 2002;121(1):164–172
  11. Shepertycky M, Banno K, Kryger MH. Gender differences in clinical presentation of patients diagnosed with obstructive sleep apnea. Sleep. 2005;28(3):309–314
  12. Mohsenin V. Gender differences in the expression of sleep-disordered breathing: role of upper airway dimensions. Chest. 2001;120(5):1442–1447
  13. Walker RP, Durazo-Arvizu R, Wachter B, Gopalsami C. Preoperative differences between male and female patients with sleep apnea. Laryngoscope. 2001;111(9):1501–1505
  14. Leech J, Onal E, Dulberg C, Lopata M. A comparison of men and women with occlusive sleep apnea syndrome. Chest. 1998;94(5):983–987
  15. O'Connor C, Thornley KS, Hanly P. Gender influence in the polysomnographic features of obstructive sleep apnea. Am J Respir Crit Care Med. 2000;161(5):1465–1472
  16. Ware JC, McBrayer RH, Scott JA. Influence of sex and age on duration and frequency of sleep apnea events. Sleep. 2000;23(2):165–169
  17. American Academy of Sleep Medicine Task Force. Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep. 1999;22(5):667–689
  18. Rechtshaffen A, Kales A. A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Washington, DC: National Institutes of Health US Government Printing Office [Publication no. 24].
  19. Stradling JR. Normal sleep and breathing. In:  Stradling JR editors. Handbook of sleep-related breathing disorders. Oxford: Oxford Medical Publications; 1993;p. 5–22
  20. Guilleminault C, Quera-Salva MA, Partinen M, Jamieson A. Women and obstructive sleep apnea syndrome. Chest. 1998;93(1):104–109
  21. Rajala R, Partinen M, Sane T, et al. Obstructive sleep apnea in morbidly obese patients. J Intern Med. 1991;230:125–129
  22. Dancey RD, Hanly PJ, Soong C, et al. Impact of menopause in the prevalence and severity of sleep apnea. Chest. 2001;120:151–155
  23. Collop NA, Adkins D, Plillips BA. Gender differences in sleep and sleep-disordered breathing. Clin Chest Med. 2004;25(2):257–268
  24. Hume KI, Van F, Watson A. A field study of age and gender differences in habitual adult sleep. J Sleep Res. 1998;7:85–94
  25. Kobayashi R, Kohsaka M, Fukuda N, et al. Gender differences in the sleep of middle-aged individuals. Psychiatry Clin Neurosci. 1998;52(2):186–187
  26. Ehlers CL, Kupfer DJ. Slow-wave sleep: do young adult men and women age differently?. J Sleep Res. 1997;6:211–215
  27. Ohayon M. Epidemiological study on insomnia in a general population. Sleep. 1996;19:7–15
  28. Moline ML, Broch L, Zak R, Gross V. Sleep in women across the life cycle from adulthood to menopause. Sleep Med Rev. 2003;7:155–177
  29. Kapsimalis F, Kryger M. Gender and obstructive sleep apnea syndrome, part 2: mechanisms. Sleep. 2002;25(5):499–506
  30. Rowley JA, Zhou X, Vergine I, et al. Influence of gender on upper airway mechanics: upper airway resistance and Pcrit. J Appl Physiol. 2001;91(5):2248–2254
  31. Popovic RM, White DP. Upper airway muscle activity in normal women: influence of hormonal status. J Appl Physiol. 1998;84(3):1055–1062
  32. Kunitomo F, Kimura H, Tatsumi K, et al. Sex differences in awake ventilatory drive and abnormal breathing during sleep in eucapneic obesity. Chest. 1988;93(5):968–975
  33. Popovic RM, White DP. Influence of gender on waking genioglossus electromyogram and upper airway resistance. Am J Respir Crit Care Med. 1995;152:725–731
  34. Jordan AS, Catcheside PG, O'Dononghue FJ, et al. Selected contribution: genioglossus muscle activity at rest and in response to brief hypoxia in healthy men and women. J Appl Physiol. 2002;92(1):410–417
  35. Trinder J, Kay A, Kleiman J, Dunai J. Gender differences in airway resistance during sleep. J Appl Physiol. 1997;83(6):1986–1997
  36. Cistulli PA, Barnes DJ, Grunstein RR, Sullivan CE. Effect of short term hormone replacement in the treatment of obstructive sleep apnea in postmenopausal women. Thorax. 1994;46:699–702
  37. Quintana-Gallego E, Carmona-Bernal C, Capote F, et al. Gender differences in obstructive sleep syndrome: a clinical study of 1166 patients. Respir Med. 2004;98(10):984–989

PII: S1389-9457(06)00012-8

doi: 10.1016/j.sleep.2005.12.014

Sleep Medicine
Volume 7, Issue 5 , Pages 424-430 , August 2006

Article Tools