Sleep Medicine
Volume 7, Issue 5 , Pages 431-435 , August 2006

S100B and NSE serum levels in obstructive sleep apnea syndrome

  • Carla W. Braga

      Affiliations

    • Departamento de Bioquimica, Rua Ramiro Barcelos 2600 anexo, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
    • ,
  • Denis Martinez

      Affiliations

    • Cardiology Service, Hospital de Clinicas de Porto Alegre, UFRGS, Brazil
    • ,
  • Susana Wofchuk

      Affiliations

    • Departamento de Bioquimica, Rua Ramiro Barcelos 2600 anexo, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
    • ,
  • Luis V. Portela

      Affiliations

    • Departamento de Bioquimica, Rua Ramiro Barcelos 2600 anexo, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
    • ,
  • Diogo Onofre Souza

      Affiliations

    • Departamento de Bioquimica, Rua Ramiro Barcelos 2600 anexo, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55 51 3316 5558; fax: +55 51 3316 5540.

Received 12 May 2005 ,Revised 29 November 2005 ,Accepted 29 December 2005.

References 

  1. Flemons WW. Obstructive sleep apnea. N Eng J Med. 2002;347(7):498–504
  2. Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The report of an American academy of sleep medicine task force. Sleep 1999;22(5):667–89.
  3. Lavie P, Lavie L, Herer P. All-cause mortality in males with sleep apnoea syndrome: declining mortality rates with age. Eur Respir J. 2005;25(3):514–520
  4. Beebe DW, Gozal D. Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits. J Sleep Res. 2002;11(1):1–16
  5. Engleman HM, Kingshott RN, Martin SE, Douglas NJ. Cognitive function in the sleep apnea/hypopnea syndrome (SAHS). Sleep. 2000;23(Suppl. 4):S102–S108
  6. Akashiba T, Kawahara S, Akahoshi T, et al. Relationship between quality of life and mood or depression in patients with severe obstructive sleep apnea syndrome. Chest. 2002;122(3):861–865
  7. Sassani A, Findley LJ, Kryger M, et al. Reducing motor-vehicle collisions, costs, and fatalities by treating obstructive sleep apnea syndrome. Sleep. 2004;27(3):453–458
  8. El-Ad B, Lavie P. Effect of sleep apnea on cognition and mood. Int Rev Psychiatry. 2005;17(4):277–282
  9. Mooe T, Franklin KA, Holmstrom K, et al. Sleep-disordered breathing and coronary artery disease: long-term prognosis. Am J Respir Crit Care Med. 2001;164(10):1910–1913
  10. Lavie P. Pro: sleep apnea causes cardiovascular disease. Am J Respir Crit Care Med. 2004;169(2):147–148
  11. Marti S, Sampol G, Munoz X, et al. Mortality in severe sleep apnoea/hypopnoea syndrome patients: impact of treatment. Eur Respir J. 2002;20(6):1511–1518
  12. Pressman MR, Schetman WR, Figueroa WG, et al. Transient ischemic attacks and minor stroke during sleep. Relationship to the obstructive sleep apnea syndrome. Stroke. 1995;26(12):2361–2365
  13. Hermann DM, Bassetti CL. Sleep-disordered breathing and stroke. Curr Opin Neurol. 2003;16(1):87–90
  14. Young T, Palta M, Dempsey J, et al. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993;328(17):1230–1235
  15. Bartlett DJ, Rae C, Thompson CH, et al. Hippocampal area metabolites relate to severity and cognitive function in obstructive sleep apnea. Sleep Med. 2004;5(6):593–596
  16. Prabhakar NR, Fields RD, Baker T, Fletcher EC. Intermittent hypoxia: cell to system. Am J Physiol Lung Cell Mol Physiol. 2001;281(3):L524–L528
  17. Brooks D, Horner RL, Kimoff RJ, et al. Effect of obstructive sleep apnea versus sleep fragmentation on responses to airway occlusion. Am J Respir Crit Care Med. 1997;155(5):1609–1617
  18. Martens P, Raabe A, Johnsson P. Serum S-100 and neuron-specific enolase for prediction of regaining consciousness after global cerebral ischemia. Stroke. 1998;29(11):2363–2366
  19. Peskind ER, Griffin WS, Akama KT, et al. Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease. Neurochem Int. 2001;39(5–6):409–413
  20. Portela LV, Brenol JC, Walz R, et al. Serum S100B levels in patients with lupus erythematosus: preliminary observation. Clin Diagn Lab Immunol. 2002;9(1):164–166
  21. Schmidt AP, Tort AB, Amaral OB, et al. Serum, S100B protein in pregnancy-related hypertensive disorders: a case-control study. Clin Chem. 2004;50(2):435–438
  22. Donato R. Intracellular and extracellular roles of S100 proteins. Microsc Res Tech. 2003;60(6):540–551
  23. Kayser E, Kaiser R, Kuzmits P, et al. Clinical biochemistry of neuron specific enolase. Clin Chim Acta. 1989;183(1):13–32
  24. Herrmann M, Vos P, Wunderlich MT, et al. Release of glial tissue-specific proteins after acute stroke a comparative analysis of serum concentrations of protein S-100B and glial fibrillary acidic protein. Stroke. 2000;31(11):2670–2677
  25. Pleines UE, Morganti-Kossmann MC, Rancan M, Joller H, Trentz O, Kossmann T. S-100 beta reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe traumatic brain injury. J Neurotrauma. 2001;18(5):491–498
  26. Van Eldik LJ, Wainwright MS. The Janus face of glial-derived S100B: beneficial and detrimental functions in the brain. Restor Neurol Neurosci. 2003;21(3–4):97–108
  27. Ahlemeyer B, Beier H, Semkova I, et al. S-100 beta protects cultured neurons against glutamate- and staurosporine-induced damage and is involved in the antiapoptotic action of the 5 HT(1A)-receptor agonist, Bay x 3702. Brain Res. 2000;858(1):121–128
  28. Walz R, Portela LV, Tort AB, et al. Serum S100B levels in patients with HTLVI- associated myelopathy/tropical spastic paraparesis. Neurology. 2000;54(10):2021–2029
  29. Jordan W, Hagedohm J, Wiltfang J, et al. Biochemical markers of cerebrovascular injury in sleep apnoea syndrome. Eur Respir J. 2002;20(1):158–164
  30. Portela LV, Tort AB, Schaf DV, et al. The serum S100B concentration is age dependent. Clin Chem. 2002;48(6):950–952
  31. Chervin RD. Epworth sleepiness scale?. Sleep Med. 2003;4(3):175–176
  32. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. The mini-international neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59(Suppl. 20):22–33[quiz 34–57]
  33. Rechtschaffen A, Kales AA. A manual of standardized terminology, techniques, and scoring system for sleep stages of human subjects. Washington, DC: Public Health Service; 1968;
  34. Kulpa J, Wojcik E, Reinfuss M, Kolodziejski L. Carcinoembryonic antigen, squamous cell carcinoma antigen, CYFRA 21-1, and neuron-specific enolase in squamous cell lung cancer patients. Clin Chem. 2002;48(11):1931–1937
  35. Kotterba S, Rasche K, Widdig W, et al. Neuropsychological investigations and event-related potentials in obstructive sleep apnea syndrome before and during CPAP-therapy. J Neurol Sci. 1998;159(1):45–50
  36. Gale SD, Hopkins RO. Effects of hypoxia on the brain: neuroimaging and neuropsychological findings following carbon monoxide poisoning and obstructive sleep apnea. J Int Neuropsychol Soc. 2004;10(1):60–71
  37. Decary A, Rouleau I, Montplaisir J. Cognitive deficits associated with sleep apnea syndrome: a proposed neuropsychological test battery. Sleep. 2000;23(3):69–81
  38. Naegele B, Thouvard V, Pepin JL, et al. Deficits of cognitive executive functions in patients with sleep apnea syndrome. Sleep. 1995;18(1):43–52
  39. Ong KC, Clerk AA. Comparison of the severity of sleep-disordered breathing in Asian and Caucasian patients seen at a sleep disorders center. Respir Med. 1998;92(6):843–848
  40. Schroder CM, O'Hara R. Depression and obstructive sleep apnea (OSA). Ann Gen Psychiatry. 2005;4:13–20

PII: S1389-9457(06)00007-4

doi: 10.1016/j.sleep.2005.12.012

Sleep Medicine
Volume 7, Issue 5 , Pages 431-435 , August 2006

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