Sleep Medicine
Volume 4, Issue 4 , Pages 281-284 , July 2003

Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients

  • Bradley F Boeve

      Affiliations

    • Sleep Disorders Center, Mayo Clinic, 200 First Street SW, Rochester, MN, USA
    • Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    • Alzheimer's Disease Research Center, Mayo Foundation, Jacksonville, FL, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-507-284-8983; fax: +1-507-266-4752
  • ,
  • Michael H Silber

      Affiliations

    • Sleep Disorders Center, Mayo Clinic, 200 First Street SW, Rochester, MN, USA
    • Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
  • ,
  • Tanis J Ferman

      Affiliations

    • Alzheimer's Disease Research Center, Mayo Foundation, Jacksonville, FL, USA
    • Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, USA

Received 3 September 2002 ,Revised 12 February 2003 ,Accepted 14 February 2003.

References 

  1. Schenck C, Mahowald M. A polysomnographic, neurologic, psychiatric and clinical outcome report on 70 consecutive cases with REM sleep behavior disorder (RBD): sustained clonzepam efficacy in 89.5% of 57 treated patients. Clev Clin J Med. 1990;57(suppl):10–24
  2. Sforza E, Krieger J, Petiau C. REM sleep behavior disorder: clinical and physiopathological findings. Sleep Med Rev. 1997;1:57–69
  3. Olson E, Boeve B, Silber M. Rapid eye movement sleep behavior disorder: demographic, clinical, and laboratory findings in 93 cases. Brain. 2000;123:331–339
  4. Schenck C, Mahowald M. REM sleep behavior disorder: clinical, developmental, and neuroscience perspectives 16 years after its formal identification in SLEEP. Sleep. 2002;25:120–138
  5. Kunz D, Bes F. Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation. Mov Disord. 1999;14:507–511
  6. Takeuchi N, Uchimura N, Hashizume Y, et al.  Melatonin therapy for REM sleep behavior disorder. Psychiatry Clin Neurosci. 2001;55:267–269
  7. Boeve B. Melatonin for treatment of REM sleep behavior disorder: response in 8 patients. Sleep. 2001;24:A374
  8. International Classification of Sleep Disorders: Diagnostic and Coding Manual, Revised. Rochester, MN: American Sleep Disorders Association; 1997;
  9. Boeve BF, Silber MH, Ferman TJ, et al.  REM sleep behavior disorder and degenerative dementia: an association likely reflecting Lewy body disease. Neurology. 1998;51:363–370
  10. Ferman TJ, Boeve BF, Smith GE, et al.  REM sleep behavior disorder and dementia: cognitive differences when compared with AD. Neurology. 1999;52:951–957
  11. Boeve B, Silber M, Ferman T, Lucas J, Parisi J. Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy. Mov Disord. 2001;16:622–630
  12. Ferman T, Boeve B, Smith G, et al.  Dementia with Lewy bodies may present as dementia with REM sleep behavior disorder without parkinsonism or hallucinations. J Int Neuropsychol Soc. 2002;8:907–914
  13. McKeith IG, Galasko D, Kosaka K, et al.  Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology. 1996;47:1113–1124
  14. McKeith IG, Perry EK, Perry RH. Report of the second dementia with Lewy body international workshop: diagnosis and treatment. Consortium on Dementia with Lewy bodies. Neurology. 1999;53:902–905
  15. Diagnostic and Statistical Manual of Mental Disorders. 3rd ed.. Washington, DC: American Psychiatric Association; 1987;
  16. Petersen R, Smith G, Waring S, et al.  Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999;56:303–308
  17. Wenning G, Shlomo T, Magelhaes M, et al.  Clinical features and natural history of multiple system atrophy: an analysis of 100 cases. Brain. 1994;117:835–845
  18. Silber M, Krahn L, Olson E, Pankratz V. The epidemiology of narcolepsy in Olmsted County, Minnesota: a population-based study. Sleep. 2002;25:197–202
  19. Lapierre O, Montplaisir J. Polysomnographic features of REM sleep behavior disorder: development of a scoring method. Neurology. 1992;42:1371–1374
  20. Ringman J, Simmons J. Treatment of REM sleep behavior disorder with donepezil: a report of three cases. Neurology. 2000;55:870–871

 Presented in part at the Annual Meeting of the Associated Professional Sleep Societies in Chicago, IL in June 2001.

PII: S1389-9457(03)00072-8

doi: 10.1016/S1389-9457(03)00072-8

Sleep Medicine
Volume 4, Issue 4 , Pages 281-284 , July 2003