Sleep Medicine
Volume 2, Issue 4 , Pages 365-366 , July 2001

Law of denervation and spinal mechanism of leg movements in sleep: Commentary on controversies in sleep medicineMontplaisir et al.: Periodic leg movements are not more prevalent in insomnia or hypersomnia but are specifically associated with sleep disorders involving a dopamineergic mechanism

  • S.I Peimer

      Affiliations

    • Corresponding Author Information4522 Lashley Court, Marietta, GA 30068, USA. Tel.: +1-770-579-6246; fax: +1-770-448-3350

References 

  1. Montplaisir J, Michaud M, Denesle R, Gosselin A. Periodic leg movements are not more prevalent in insomnia or hypersomnia but specifically associated with sleep disorders involving a DE impairment. Sleep Med. 2000;1(2):163–167
  2. Holstege JC, Van Dijken H, Buijs RM, et al.  Distribution of dopamine immunoreactivity in the rat, cat and monkey spinal cord. J Comp Neurol. 1996;376(4):631–652
  3. Bara-Jimenez W, Aksu M, Graham B, et al.  Periodic limb movements in sleep. State-dependent excitability of the spinal flexor reflex. Neurology. 2000;54(8):1609–1615
  4. Lindvall O, Bjorklund A, Skagerberg G. Dopamine-containing neurons in the spinal cord: anatomy and some functional aspects. Ann Neurol. 1983;14(3):255–260
  5. Orbeli LA, Kunzman KI. About the consequences of deafferentation of hind limb in dogs. First published in the Russian Physiological Journal, 1921;4(1–6) In:  Orbeli LA editors. Selected works. Moscow: Academy of Sciences of the USSR; 1964;p. 77–82
  6. Chokroverty S, Jankovic J. Restless legs syndrome. A disease in search of identity. Neurology. 1999;52:907–910
  7. Cannon WB. A law of denervation. Science. 1939;89:439
  8. Cannon WB, Haimovich H. The sensitization of motoneurones by partial ‘denervation’. Am J Physiol. 1939;126:731–740
  9. Peimer SI, Rosenberg R. Coupling of leg movements with breathing cycle in sleep. Sleep. 1999;22(Suppl 1):S70–S71

PII: S1389-9457(01)00105-8

Sleep Medicine
Volume 2, Issue 4 , Pages 365-366 , July 2001

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