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Sleep Medicine
Volume 1, Issue 2
, Pages 87-90
, 1 April 2000
Perspectives in narcolepsy and hypocretin (orexin) research
References
- Hypocretin (orexin) deficiency in human narcolepsy. Lancet. 2000;355(9197):39–40
- The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell. 1999;98(3):365–376
- Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell. 1999;98(4):437–451
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The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.
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- Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998;92(4):573–585
- Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci. 1998;18(23):9996–10015
- Distribution of orexin neurons in the adult rat brain. Brain Res. 1999;827(1–2):243–260
- Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin. J Neurosci. 1998;18(19):7962–7971
- Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system. J Comp Neurol. 1999;415(2):145–159
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Orexin A activates locus coeruleus cell firing and increases arousal in the rat.
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- Distribution of orexin receptor mRNA in the rat brain. FEBS Lett. 1998;438(1–2):71–75
- Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems. J Neurosci. 1993;13(3):1057–1064
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- . Pharmacological aspects of human and canine narcolepsy. Prog Neurobiol. 1997;52(1):27–78
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- . Orexin synthesis and response in the gut. Neuron. 1999;24(4):941–951
PII: S1389-9457(00)00013-7
© 2000 Elsevier Science B.V. All rights reserved.
Next »
Sleep Medicine
Volume 1, Issue 2
, Pages 87-90
, 1 April 2000
